PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice.
Lung epithelial and endothelial cell death accompanied by inflammation contributes to hyperoxia-induced acute lung injury (ALI).Impaired resolution of ALI can promote and/or perpetuate lung pathogenesis, including fibrosis.Previously, we have shown that the transcription factor Nrf2 induces cytoprotective gene expression and confers protection agai